Kambo is applied through small points on the skin — superficial micro-openings that allow the secretion to enter the body. To create them, only a thin layer of the epidermis is gently removed. In an initial session, 3–5 points are typically opened, and before beginning, it is recommended to drink about half a liter of water to prepare the body.

Once applied, Kambo’s effects appear quickly but are temporary, lasting approximately 20–25 minutes.

First Minutes: Between 30 seconds and the first minute, a rise in body heat may be felt, accompanied by a slight increase in pulse and a sensation of pressure in the head. Tingling or numbness may appear in the lips, tongue, and ears, as well as dizziness or light-headedness. These sensations usually last 5–7 minutes.

Release Phase: During the next 10–20 minutes, some people experience flu-like symptoms such as nausea, weakness, or body aches. In certain cases, purging (vomiting) may occur, although it is not required for Kambo to take effect. 

After this phase, symptoms quickly subside. The body enters a state of deep relaxation, sometimes accompanied by mental clarity or mild euphoria. After a short recovery period of 30–45 minutes, most people can resume normal activities.

Many participants report that Kambo’s benefits continue to manifest hours or days later, and some perceive lasting positive effects for weeks or even months.