Specific Benefits Backed by Evidence

Kambo, the natural secretion of the Amazonian Phyllomedusa bicolor frog, has been used for centuries by Indigenous communities as an ally in cultivating physical strength, endurance, and purification of the body. Today, scientific interest in its bioactive peptides offers a deeper understanding of the physiological and emotional effects many participants report after a session.

1. STIMULATION OF THE IMMUNE SYSTEM

Peptides such as dermaseptins and adenoregulin interact with the lymphatic system, supporting toxin elimination and the activation of natural defenses. Anecdotally — and supported by preclinical studies — many users report increased resistance to common infections and a profound sense of purification.

2. SUPPORT FOR DETOXIFICATION AND BODILY CLEANSING

The purging process characteristic of Kambo — including vomiting, sweating and intestinal release — is not merely symbolic; it activates real physiological cleansing mechanisms. By stimulating digestive secretions and intestinal motility — thanks to peptides such as phyllocaerulein — the body releases accumulated waste, helping to restore homeostasis.

3. EMOTIONAL REGULATION AND MENTAL CLARITY

Many participants describe a profound sense of emotional reset after a Kambo session. This effect may be related to the release of endorphins and the modulation of neurotransmitters such as serotonin and dopamine, associated with peptides like deltorphin and dermorphin. These processes promote calm, focus and emotional well-being.

4. ANALGESIC AND PAIN-MODULATING POTENTIAL

Kambo’s natural opioid peptides — dermorphin and deltorphin — exhibit analgesic potency significantly greater than that of morphine, yet without the addictive potential of synthetic opioids. Although their clinical use remains under investigation, this effect may contribute to the sense of relief and physical lightness many participants report after a ceremony.

5. INCREASE IN VITALITY AND PHYSICAL ENERGY

The combined effects of physical cleansing, emotional release and immune stimulation often result in a marked increase in vitality. Many participants describe feeling lighter, more focused and energized — with a renewed sense of clarity and motivation after the session.